Effects of orthostatic hypotension on cognition in Parkinson disease

Orthostatic hypotension in de novo Parkinson disease.

BACKGROUND It is accepted that orthostatic hypotension is a clinical marker for the diagnosis of multiple system atrophy, but conflicting data indicate that it may also be present in Parkinson disease (PD). OBJECTIVES To evaluate the prevalence of autonomic cardiovascular impairment and orthostatic hypotension in a large group of patients with de novo PD, followed up for at least 7 years, to ...

Orthostatic hypotension in Iranian patients with Parkinson`s disease.

OBJECTIVE To prospectively investigate the prevalence and clinical relevance of orthostatic hypotension (OH) in Parkinson`s disease (PD) in Isfahan, Iran. METHODS We investigated 150 consecutive patients with PD (42 women, 108 men) in Al-Zahra Hospital, Isfahan, Iran from January 2002 to January 2004. Blood pressure was measured first in a supine position following a rest of at least 10 minut...

Orthostatic hypotension in Parkinson's disease.

Droxidopa and Reduced Falls in a Trial of Parkinson Disease Patients With Neurogenic Orthostatic Hypotension

OBJECTIVES Droxidopa is a prodrug of norepinephrine indicated for the treatment of orthostatic dizziness, lightheadedness, or the "feeling that you are about to black out" in adult patients with symptomatic neurogenic orthostatic hypotension caused by primary autonomic failure including Parkinson disease (PD). The objective of this study was to compare fall rates in PD patients with symptomatic...

Cognition and hopelessness in association with subsyndromal orthostatic hypotension.

BACKGROUND The move from lying to standing is typically associated with a variety of physiological and neurohumoral changes, most especially a slight increase in systolic blood pressure (SBP). Decreased efficacy of the various mechanisms that control orthostatic blood pressure (BP) regulation may result in lightheadedness, dizziness, syncope, and cerebral hypoperfusion. The lack of effective or...